Let’s start with the 4 actives we already covered: L-ascorbic acid (vitamin C), AHAs (glycolic, lactic, mandelic acids), niacinamide, and retinol.
Actives relationship map As you can see, in this crude breakdown, it can get confusing even with just 4 actives. Niacinamide and Vitamin C don’t work well together in skincare because when mixed together they make brown [metaphorically!] Secondly, Niacinamide and acidic skincare ingredients have some ‘chemistry’ going on *wink wink*. WHY USE our NIACINAMIDE SERUM WITH HYALURONIC ACID Known as the “up-and-coming” skin care ingredient of choice, Niacinamide has been gaining a lot of media attention lately as the newest “wonder” for aging skin, and for good reason! That means you'd be missing out on all the benefits your acid has to offer. Literal chemistry.

When you mix them together, the niacinamide will raise the pH of the acid.

and you can’t un-mix them again to get their awesome skin benefits. While it’s … Mixed together they become ‘in-active’.

What about vitamin C and niacinamide? This studycompared the absorption of AHAs at pH 3.0 and 7.0, and found that the higher the pH, the less the skin absorbs. Hyaluronic acid and niacinamide are both water-based treatment and they can be used together.

In this way, you can replenish your skin with plenty of hydration first. Then apply niacinamide to regulates your sebum and minimizes pores. When used together, start by applying hyaluronic acid then followed by niacinamide.
The question is whether ascorbic acid (such as L-ascorbic acid) converts niacinamide to niacin, a form which can cause flushing.


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